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microglia    
小神经胶质; 格子细胞

小神经胶质; 格子细胞


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  • Protective Microglia Unmasked: They Act Like Regulatory T Cells
    PU 1-low microglia were rare, making up less than 1 percent of the total To a “T ” A subtype of regulatory microglia express many of the immunomodulatory receptors typically found on T cells, such as CD28, PD1, CD5, and CTLA-2 Downstream, these receptors activate phospholipase Cγ [Courtesy of Ayata et al , 2025, Nature ]
  • New PET Tracers Visualize Activated and Homeostatic Microglia
    In trying to treat neuroinflammation, scientists need better ways to visualize microglia in the brains of living people Current microglial PET tracers target the mitochondrial transporter TSPO, but TSPO crops up in other cell types as well Several groups are working on new options In one such
  • After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods
    Microglia also took on distinct signatures depending on the extent of amyloid clearance in their neighborhood For example, in cases of extensive plaque clearance, the cells upregulated myristoylated alanine-rich C kinase substrate, a protein involved in cell motility and phagocytosis, and fibroblast growth factor receptor 3 in addition to ApoE
  • Lipid-Laden, Sluggish Microglia? Blame Aβ. | ALZFORUM
    Microglia and macrophages make lipid droplets when stressed by inflammation Scientists believe the lipids sustain the cells’ metabolic need, enabling them to respond to threats (van Dierendonck et al , 2022; reviewed by Olzmann and Carvalho, 2019) Wyss-Coray previously described lipid-droplet accumulating microglia (LDAMs) that spewed pro-inflammatory cytokines in the hippocampi of old
  • ACE Supercharges Microglia to Shrink Plaques | ALZFORUM
    Mouse microglia got a genetic tune-up On 9 June in Nature Aging, researchers led by Warren G Tourtellotte at Cedars-Sinai Medical Center in Los Angeles reported that expressing human angiotensin-converting enzyme (ACE) in mouse microglia boosts their uptake of Aβ, clearing out plaques in a model
  • C5aR1+ microglia exacerbate neuroinflammation and cerebral edema in . . .
    Together, these findings establish C5aR1-positive microglia as a central driver of neuroinflammation-induced cerebral edema and highlight microglial C5aR1 as a promising therapeutic target for acute brain injury
  • AD Gene PICALM Hampers Phagocytosis, Promotes Lipid Droplets in Microglia
    Overexpressing PICALM soothed microglia, dropping lipid droplets back to normal levels Priyanka Narayan at the National Institutes of Health in Bethesda, Maryland, was struck by how much these PICALM phenotypes resemble APOE4 biology, which also involves dysregulated lipids, lysosomes, and phagocytosis, along with accumulation of lipid droplets
  • Paper Alert: APOE4 Packs on Lipid Droplets in Microglia
    Last year, scientists led by Tony Wyss-Coray, Stanford University, reported that Aβ induced formation of lipid droplets within human microglia, and attributed this to an uptick in a triglyceride synthesis enzyme APOE4 aggravated lipid droplet formation, and APOE4 4 carriers who had had Alzheimer
  • A Tale of Two T Cells—Slowing Tau Spread, Shredding White Matter
    Microglia join forces with CD8⁺ T cells In tauopathy mice, these cells slow the spread of pathology But in older wild types, they contribute to axon loss





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