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  • Kinetochore - Wikipedia
    The kinetochore assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis The term kinetochore was first used in a footnote in a 1934 Cytology book by Lester W Sharp [2] and commonly accepted in 1936 [3]
  • What Is a Kinetochore and Why Is It Important? - Biology Insights
    A kinetochore is a complex protein structure on chromosomes that serves as the attachment point for spindle microtubules, which pull chromosomes apart This mechanism is fundamental for ensuring genetic material is accurately distributed during cell division
  • What is a Kinetochore? - ThoughtCo
    A kinetochore is a protein patch on chromosomes that helps move them during cell division Kinetochores connect to spindle fibers to ensure chromosomes are divided correctly between new cells
  • A Molecular View of Kinetochore Assembly and Function - PMC
    The outer kinetochore is the (main) platform for end-on microtubule binding by the kinetochore and responsible for transducing the force generated by depolymerizing microtubules to move chromosomes
  • Kinetochore structure and function: Trends in Cell Biology
    The vertebrate kinetochore is a complex structure that specifies the attachments between the chromosomes and microtubules of the spindle and is thus essential for accurate chromosome segregation
  • Kinetochore - an overview | ScienceDirect Topics
    Kinetochore Assembly and Function The kinetochore is a large protein complex that assembles on a specialized region of the chromosome called the ‘centromere’ The kinetochore mediates microtubule attachment to the chromosome, thereby promoting its proper segregation during mitosis
  • Molecular architecture of the kinetochore–microtubule interface
    The kinetochore is composed of a number of conserved protein complexes that direct its specification and assembly, bind to spindle microtubules and regulate chromosome segregation
  • Proteomics reveals extensive phosphoregulation of outer kinetochore . . .
    Microtubules attach to kinetochores to facilitate chromosome movement to opposite spindle poles Defective kinetochore-microtubule attachments lead to phosphorylation of the outer kinetochore protein KNL1 at conserved MELT motifs, which triggers spindle assembly checkpoint activation and recruitment of the fibrous corona To identify additional phosphorylation sites that regulate kinetochores





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